Creating a New Class of Curative Medicines


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Self-Assembly of Hybrid Graft Copolymers


Refolding Hydrogels Self-Assembled from HPMA Graft Copolymers by Antiparallel Coiled-Coil Formation

Yang J, Xu C, Wang C, Kopeček J; Biomacromolecules 7, 1187-1195 (2006)

Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers

Yang J, Wu K, Koňák Č, Kopeček J; Biomacromolecules 9, 510-517 (2008)

HPMA Copolymers Conjugated to Multiple Fab' Fragments

Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20

Johnson RN, Kopečková P, Kopeček J; Bioconjugate Chemistry 20, 129-137 (2009)

Biological Activity of Anti-CD20 Multivalent HPMA Copolymer-Fab’ Conjugates

Johnson RN, Kopečková P, Kopeček J; Biomacromolecules 13, 727-735 (2012)

Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis

Chu TW, Yang J, Kopeček J; Biomaterials 33, 7174-7181 (2012)

Coiled-Coil Based Drug-Free Macromolecular Therapeutics

Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil-Mediated Cross-Linking of Antigens on the Cell Surface

Wu K, Liu J, Johnson RN, Kopeček J; Angew. Chem. Int. Ed. 49, 1451-1455 (2010)


Coiled-coil based drug-free macromolecular therapeutics: In vivo efficacy

Wu K, Yang J, Liu J, Kopeček J; J. Controlled Release 157, 126-131 (2012)

Immunogenicity of coiled-coil based drug-free macromolecular therapeutics

Kverka M, Hartley JM, Chu TW, Yang J, Heidchen R, Kopeček J; Biomaterials 35, 5886-5896 (2014)

Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a “Drug Free” Therapeutic System

Zhang R, Yang J, Chu TW, Hartley JM, Kopeček J; Adv. Healthcare Mat. (2015) doi: 10.1002/admh.201400679

Morpholino Based Drug-Free Macromolecular Therapeutics

Cell Surface Self-Assembly of Hybrid Nanoconjugates via Oligonucleotide Hybridization Induces Apoptosis

Chu TW, Yang J, Zhang R, Sima M, Kopeček J; ACS Nano 8, 719-730 (2014)


Drug-Free Macromolecular Therapeutics Induce Apoptosis of Patient Chronic Lymphocytic Leukemia Cells

Chu TW, Kosak KM, Shami PJ, Kopeček J; Drug Delivery Translational Res. 4, 389-394 (2014)

A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab

Chu TW, Zhang R, Yang J, Chao MP, Shami PJ, Kopeček J; Theranostics, 5(8):834-846 (2015)


Drug-Free Macromolecular Therapeutics – A New Paradigm in Polymeric Nanomedicines

Chu TW, Kopeček J; Biomaterials Sci. (2015) doi: 10.1039/c4bm00442f